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speE [2017-05-24 13:07:00]
function
spermidine, polyamine biosynthesis
product
spermidine synthase
Genomic Context
categories
[category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.6|Miscellaneous metabolic pathways] → [category|SW 2.6.6.6|Metabolism of polyamines]Gene
Coordinates
3,848,786 → 3,849,616
Phenotypes of a mutant
inactivation of ''[gene|4F3E96C741561746B4E0EEA5AE29DB124C2F7249|speE]'' reduces [SW|sporulation] efficiency to 6% that of wild type cells; delayed entry into [SW|sporulation] [Pubmed|26735940]The protein
Catalyzed reaction/ biological activity
S-adenosylmethioninamine + putrescine = 5'-S-methyl-5'-thioadenosine + spermidine (according to Swiss-Prot)Protein family
spermidine/spermine synthase family (according to Swiss-Prot)Structure
[PDB|1IY9]Expression and Regulation
Operons
genes
[gene|4F3E96C741561746B4E0EEA5AE29DB124C2F7249|speE]-[gene|EA0AA0ECBC4A36A3F01F5876900FE51243D9AD07|speB]
description
[Pubmed|9723923]
sigma factors
[protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|SigA]: sigma factor, [Pubmed|9723923], in [regulon|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|SigA regulon]view in new tabBiological materials
Mutant
MGNA-A521 (ywhF::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/521 NBRP B. subtilis, Japan]BKE37500 (''[gene|4F3E96C741561746B4E0EEA5AE29DB124C2F7249|speE]''::''erm'', available in the BGSC and in [SW|Jörg Stülke]'s lab)References